polygonum multiflorum side effects
In one 28-day murine trial, oral administration of an aqueous solution of P. multiflorum affected the synthesis rates of transfer proteins and bile acid. Tetrahydroxystilbene glucoside from Fo-ti helped with memory deficit in mouse models of Alzheimer’s [10, 11]. Epub 2011 Nov 20. Can Vitamin D Reduce the Likelihood of Cancer. SelfHacked has the strictest sourcing guidelines in the health industry and we almost exclusively link to medically peer-reviewed studies, usually on PubMed. However, few clinical studies have been conducted to evaluate the traditional therapeutic claims and to understand the medical potential of its bioactive compounds. Polygonum multiflorum (PM), a traditional Chinese medicine, is used to treat various diseases including nonalcoholic fatty liver disease and hyperlipidemia. P. multiflorum may also be toxic to the kidneys (nephrotoxicity) and the lungs (pulmonary toxicity), particularly after long-term use. Definition, Function & Structure, Causes of High Uric acid, Associated Problems + Ways to Decrease. Side Effects and Benefits of Polygonum multiflorum [Chinese knotweed] Polygonum multiflorum [Chinese knotweed, Flowery knotweed; as fo-ti, fo-ti-teng, ho shou wu, or he shou wu; 何首烏] How does polygonum multiflorum (Chinese knotweed) benefit people at aging-process? Animal research shows that P. multiflorum reduces fat deposits inside the liver. People respond differently to diets and supplements because everyone has unique DNA. Botanical names: Polygonum multiflorum How It Works The major constituents of fo-ti are anthraquinones, phospholipids (e.g., lecithin), tannins, and tetrahydroxystilbene glucoside. Exhibits antioxidant & neuroprotective effects. This is especially helpful to older people. Fo Ti can have severe side effects that sometimes have been attributed wrongly to he shou wu due to this confusion. Zhongguo Zhong Yao Za Zhi. 2012 Jan 6;139(1):287-93. doi: 10.1016/j.jep.2011.11.022. Further research is required to understand the potential heart-friendly effects of Fo-ti. In Asia, Polygonum multiflorum is called he shou wu. Wang T, Wang JY, Zhou ZX, Jiang ZZ, Li YY, Zhang L, Zhang LY. Atherosclerosis 2. In mouse models of Parkinson’s Disease, TSG and an ethanol extract of Fo-ti protected dopaminergic neurons from chemical-induced damage [30, 31]. This site uses Akismet to reduce spam. Planta Med 2010;76(9):889-92. Fo-ti, together with red ginseng, helped with metabolic syndrome in a study on rats by improving : Scientists observed the potential of emodin from Fo-ti to suppress the growth of colon and gallbladder cancer in mice [35, 36]. The type of fo-ti typically used is red fo-ti, which is the root boiled in a liquid made with black beans. Align your health hacks with your genes for optimal health & cognitive function. Gao X1, Hu YJ, Fu LC. Multiple cases of hepatotoxicity due to P. multiflorum have been reported in patients from Australia, China, Italy, Japan, the Netherlands and Slovakia who were taking the product for hair loss, chronic prostatitis or to boost the immune system [3, 41, 42, 43]. According to the Natural Medicines Comprehensive Database, oral usage is considered “possibly unsafe” for adults and children due to several reports of liver damage. TSG from Fo-ti extract protected the bone-making cells (osteoblasts) from oxidative stress in a cell-based study . Ever try supplements that don’t seem to work? Start slow and titrate up if ... Read More He or she would be able to generate better insight on the effects of the extract on your health profile. The significance of the plant is from the reddish roots which are usually boiled with black beans to form a preparation called the red Fo-ti. Note that each number in parentheses [1, 2, 3, etc.] However, you shouldn’t interpret them as supportive of any health benefit. Wang M1, Zhao R, Wang W, Mao X, Yu J. Lipid regulation effects of Polygoni Multiflori Radix, its processed products and its major substances on steatosis human liver cell line L02. In the tissue culture study, brain cells exposed to excessive levels of the activating neurotransmitter glutamate showed signs of oxidative damage and early death. This alkaloid demonstrates regulating effects on blood lipids and is being explored for its cardioprotective benefits. Keep in mind that the safety profile of Fo-ti is relatively unknown, given the lack of well-designed clinical studies. Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. Your email address will not be published. Joe Cohen won the genetic lottery of bad genes. Han MN1, Lu JM1, Zhang GY1, Yu J1, Zhao RH1. An extensive search of 6 medical databases was performed up to June 2014. If you are considering a Polygonum multiflorum … (HSW), we provide a systematic review of case reports and case series about liver damage associated with HSW. Warfarin (prescribed to prevent the formation of blood clots) may interact negatively with P. multiflorum resulting in bone marrow suppression . P. multiflorum and its extracts should be considered hepatotoxic; however, the plant is widely used in traditional Chinese medicine and Ayurvedic medicine for its rejuvenating and toning properties, to increase liver and kidney function, for treatment of cognitive di… Medical body long technical science tests, difficult logical reasoning and reading comprehension tests studies that have examined this 18. Glycosides from Fo-ti extract protected the heart from squeezing pressure around the abdomen [ 14 ] medicine... 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